Guanethidine-resistant hypertension.

Patient acceptance of guanethidine as therapy for mild to moderate hypertension. A comparison with reserpine.

The relative benefits and risks of reserpine and guanethidine were compared in patients with thiazide-treated mild to moderate hypertension (diastolic pressure 95-115 mm Hg). Forty-nine ambulant patients )30 men, 19 women) were treated throughout the study with hydrochlorothiazide, 50 mg/day. In this double blind crossover study each drug was added in graded increments until a predetermined the...

The anti-diabetic action of guanehidine.

A CASE was recently reported where stoppage of guanethidine treatment of hypertension in a diabetic patient resulted in a marked increase in insulin requirements and blood sugar levels (Gupta & Lillicrap, 1968). This patient had been previously receiving 20 mg guanethidine daily for 4 months for control of hypertension. An additional 24 units of soluble insulin were needed daily after guanethid...

Guanethidine in the Treatment of Hypertension.

Comparison of debrisoquine and guanethidine in treatment of hypertension.

A cross-over trail of debrisoquine and guanethidine in 32 patients showed that both drugs were equally effective in lowering both systolic and diastolic blood pressure. The degree to which they were tolerated by the patients, however, differed greatly. After three months on each drug 18 patients preferred debrisoquine, nine preferred guanethidine, and five showed no particular preference. At cu...

Patient Acceptance of Guanethidine as Therapy for Mild to Moderate Hypertension

The relative benefits and risks of reserpine and guanethidine were compared in patients with thiazide-treated mild to moderate hypertension (diastolic pressure 95-115 mm Hg). Fortynine ambulant patients (30 men, 19 women) were treated throughout the study with hydrochlorothiazide, 50 mg/day. In this double blind crossover study each drug was added in graded increments until a predetermined ther...